Thesis
Autonomous AI research
y-combinatorFall 2025Hard TechMachine LearningAutomationArtificial Intelligence🇺🇸 San Francisco3 peoplehiring
Luigi Charles, Sergio Charles · 2 co-founders
Profile coverage4 of 8 · missing Funding, Signals, Customers, Stack / tools · last run 8/8/2026
About
Thesis is an AI research lab automating AI R&D itself. We are building Darwin, a hill-climbing machine capable of searching vast combinatorial spaces of experiments. By using the outcome of every experiment to optimize the next, Darwin turns machine learning research into a compounding system rather than a sequence of manual attempts. We are directing this machine toward the grand challenges of biology and materials science. Our mission is to build the machine that discovers the next Transformer, the next AlphaFold, and the breakthroughs that push science and engineering to the absolute frontier.