Luca Pegolotti

Co-founder & CTO @Nucleo (YC F25). Ex Apple, Stanford, EPFL

Co-founder

Nucleo· Fall 2025Zürich Metropolitan Area

in LinkedIn

2025Co-founder· Nucleo (YC F25)

Founder · since 2025

Company

Nucleo (YC F25)

Role

Co-founder & CTO

current

Stage

—

no public source

Raised

—

no public source

Based

San Francisco, California, United States

current

Founder / co-founder — the company's markEmployee / research role

Source: LinkedIn work history

Profile coverage5 of 7 · missing posts, contact

Nucleo

The first Agentic platform for Oncology

Fall 2025

Experience

Career

Nucleo (YC F25)
Co-founder
Co-founder & CTO · San Francisco, California, United States · 2025 – Present
2025
Apple
Postdoctoral Researcher · Zurich, Switzerland · 2023 – 2025
2023
Siemens
Software Development Intern · Munich, Bavaria, Germany · 2016
2016
EPFL (École polytechnique fédérale de Lausanne)
Teaching Assistant · 2015
2015

Bio

I am a researcher in Applied Mathematics and AI for healthcare by training. I hold degrees from Politecnico di Milano, Italy (BSc) and EPFL, Switzerland (MSc and PhD), and have conducted research at the Stanford School of Medicine during my PhD and as a Postdoc. Before founding Nucleo, I was part of Apple Health AI, where I worked on physics-informed machine learning. I've published papers on computational methods, cardiovascular system modeling, and AI for medical images and optical sensors.